The Synthesis of Optically Active Antipyrylmethyl-Amine Derivatives

Facile synthesis of optically active imidazole derivatives.

Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding alpha-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imid...

Optically active diaryl tetrahydroisoquinoline derivatives.

In (1R,3S)-6,7-dimethoxy-3-(methoxydiphenylmethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline, C(31)H(31)NO(3), (I), and (1R,3S)-2-benzyl-3-[diphenyl(trimethylsiloxy)methyl]-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline, C(40)H(43)NO(3)Si, (II), the absolute configurations have been confirmed to be R and S at the isoquinoline 1- and 3-positions, respectively, by NMR spectroscopy experiment...

Synthesis of Some Amine Steroid Derivatives Approved!

Novel synthesis of optically active bishomotyrosine derivatives using the Friedel-Crafts reaction in triflic acid.

We report here a novel synthesis of optically active bishomotyrosine. The bishomotyrosine skeleton was constructed by using a Friedel-Crafts reaction between phenol and optically active N-Tfa-Glu(Cl)-OMe in triflic acid under the mild condition. Reduction and subsequent deprotection then afforded bishomotyrosine derivatives without any loss of optical purity.

Synthesis of magneto-optically active polyanilines

We report preparation of polyaniline (PANI) with radicals on the N-positions. Chirality of a PANI having optically active substituent is retained even upon oxidation by m-chloroperoxybenzoic acid in chloroform to generate spin species. Electron spin resonance and circular dichroism spectroscopy measurements suggest that the chiral paramagnetic properties of PANIs are derived from the combinatio...